Unfortunately it seems that when libraries or frameworks enter the room, best practices regarding usability, accessibility, and unobtrusive scripting are very easily thrown out of the window. In most cases this is not the fault of the libraries themselves, but of badly written demos (which will be copied and used as-is, no matter what you say), lack of documentation, and developers who use the libraries and their accompanying demos recklessly, without considering the consequences.
You may disagree with some or all of what I'm saying here, or agree but feel that the benefits you get from using an oversized library make up for the disadvantages. In the end, it's obviously your decision.
- James Bennet: Django and AJAX
- Jeremy Keith: Your own personal library
- Justin Palmer: Ajax: Killing Usability One Request at a Time
- Stuart Langridge: The fog of libraries
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